The efficacy and safety of a novel lipophilic formulation of. The transdermal gel is applied in a thin layer to the nonhaired portion of the inner pinnae using a concentration approximating 5 mg0. Safety of topical methimazole for the treatment of melasma. Methimazole prevents the thyroid gland from producing too much thyroid hormone. Take this medication by mouth with or without food. Methimazole is a prescription medication used to treat hyperthyroidism overactive thyroid, a condition in which the thyroid gland produces too much thyroid hormone. This methimazole price guide is based on using the discount card which is accepted at most u. Methimazole medications must be taken longterm for life to ensure continued treatment of hyperthyroidism symptoms. See what others have said about methimazole, including the effectiveness, ease of use and side effects.
Feb 21, 2020 methimazole prevents the thyroid gland from producing too much thyroid hormone. Dec 02, 2010 i increased the methimazole dose to 2. Thiafeline animalcare, available in two tablet sizes. Jun 28, 2016 a compounded medicine that is regularly seen by the ncc team is a product called transdermal methimazole for cats. If you find that the transdermal gel eventually doesnt do the trick, and you cant do pills pj is the worst piller ever, try and get the medication compounded into a liquid that you can mix with some canned food. Jul 09, 2012 the transdermal gel is applied in a thin layer to the nonhaired portion of the inner pinnae using a concentration approximating 5 mg 0.
Methimazole is commonly compounded into an oral liquid by compounding pharmacies. It is also used before thyroid surgery or radioactive iodine treatment. Every transdermal gel is packaged in a 1ml syringe and placed in a light resistant bag. The pharmacokinetics of methimazole, either applied in the form of a 5% topical formulation to facial skin or taken orally in the form of a 5mg tablet by 6 volunteers, were determined. Methimazole is also commonly compounded into a transdermal compound that can be used topically on the ears. I saw my endo tuesday, and he told me i am still a bit hypo on the meds. The prednisolone transdermal gel is applied topically to a hairless portion of the skin, typically the inner side of the ear lobe, where it absorbs through the skin into the bloodstream.
Veterinary practice news notes that it can be an effective in controlling hyperthyroidism, although it can take longer and require a higher dose of methimazole than pills to effectively treat the condition. The time at maximal concentration and elimination halflife were longer for 10 mg transdermal methimazole 5. Methimazole side effects, uses, dosage, overdose, pregnancy. Methimazole is an antithyroid medication used to treat hyperthyroidism. Methimazole transdermal gel compounded vetrxdirect. Methimazole tapazole side effects, dosage, interactions. Its life lasting cure, you cannot interrupt it, you cant suspend it, you cant skip an application. Hair may be a detriment to absorption when using a patch delivery device but. Methimazole is a medication used to treat hyperthyroidism overactive thyroid in pets, but especially cats.
Methimazole tapazole is the antithyroid drug most often recommended 2. As missmimz told you, the methimazole is not the cure, its a control over the disease. Transdermal methimazole for cats national custom compounding. The efficacy and safety of a novel lipophilic formulation. Transdermal patches provide sustained plasma concentrations of fentanyl for a 5day period lee, papich et al. Cats newly diagnosed with hyperthyroidism are treated with a transdermal formulation of methimazole at a dose of 5 mg 0. The compounds are made to fit the prescription we receive so virtually any strength can be made. I am trying to find a supplier of methimazole in transdermal gel form in the uk. At a dose of 5 mg kg per cat transdermal, the concentrations may not be adequate for cats, but 10 mg per cat was more effective. Methimazole transdermal gel compounded for cats size. This method is suggested for pets who are difficult to administer oral medication.
Tired of scratches, hunting for, wrestling, and cleaning up after your kitty every time you give her thyroid medication. Over the next 3 months, the cat continued to lose weight and the t4 remained high at 6. Feb 12, 2017 cat is on methimazole transdermal 5 mg. When the cat was rechecked in 1 month, her weight was stable, but the serum t4 was still high at 5. In the meantime, with the oral methimazole, she has gained back 1. It works by stopping the thyroid gland from making too much thyroid hormone. Cats were evaluated at weeks 0, 2, and 4, with a physical exam, body weight, cbc, biochemical panel, ua, total t4, indirect doppler blood pressure, and owner questionnaire. Have some side effects of mild headache, joint aches fatigue and tiredness. If using the transdermal gel, apply to the skin as directed by your veterinarian. Transdermal formulations of drugs that require higher total daily dosages i.
Methimazole 5 mg, 100 tablets helps improve the quality of life for cats with hyperthyroidism. Felimazole dechra veterinary products, available in three tablet sizes. My cat is on methimazole transdermal gel in her ears twice a day. Transdermal methimazole for feline hyperthyroidism juniper. Prices are for cash paying customers only and are not valid with insurance plans. Clinical efficacy of transdermal methimazole in cats with. Bova aus, sydney, australia medication methimazole. This study was performed to investigate the pharmacodynamic effects and clinical safety of transdermal methimazole in hyperthyroid cats. Methimazole in tablet form is very bitter, and it may be difficult to administer. A group of researchers from the vetsuisse faculty at the university of zurich looked at short and longterm followup in a group of cats treated with transdermal methimazole.
If kitty does not like taking pills and suspensions she is not alone. Finger cots are also provide for safe administration. Clinical efficacy and safety of transdermal methimazole in. If you have a hard time getting your patients to take. Methimazole comes in tablets of 5 milligrams mg or 10 mg. Apr 17, 2009 a group of researchers from the vetsuisse faculty at the university of zurich looked at short and longterm followup in a group of cats treated with transdermal methimazole.
Methimazole pet meds are a safer treatment option than surgery and produce rapid results once treatment begins. In addition, the effect of longterm topical applications of 5 % methimazole on the function of the thyroid gland in 20 patients with epidermal melasma was. Patterson veterinary has partnered with rood and riddle veterinary pharmacy, offering. Methimazole pet meds are a safer treatment option than surgery and produce rapid. You might be happy to learn there is an easier way her hyperthyroid medication, methimazole, can be compounded into a topical preparation by.
Hyperthyroid and methimazole transdermal gel thecatsite. It is used by vets to treat feline hyperthyroidism which occurs later in a cats life. Owners are instructed to wear exam gloves or finger cots, to apply the gel to alternate ears, and to wipe away any crusted material prior to the next dose. This is generally reserved for cats difficult or impossible to give oral medications. A small amount of gel containing medication is rubbed into the hairless area on the. All cats were rechecked between one and four weeks after starting therapy. Thirteen newly diagnosed hyperthyroid cats were treated with 5 mg 0. Cats were randomized to receive either transdermal methimazole in plo applied to the inner pinna, or oral methimazole 2. The situation may change in time, thats the reason for the 5 6 weeks blood checkups. It treats hyperthyroidism where the thyroid gland makes too much hormone. My cat malcolm only 6 years old is on it and it is keeping the worst of his symptoms. Background previous studies on transdermal methimazole have. Methimazole for the once daily transdermal treatment of cats with hyperthyroidism. Long term studies have shown that transdermal methimazole is an effective.
We dispense transdermal gels in our exclusive twistadose applicator. Aug 01, 20 the recommended starting daily dosage is 15 mg for mild hyperthyroidism, 30 to 40 mg for moderately severe hyperthyroidism, and 60 mg for severe hyperthyroidism, divided into 3 doses at 8hour intervals. Bova aus, sydney, australia medication methimazole bova. Efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism. Fortunately, another format for methimazole administration has emerged. Veterinary bulletin faqs about hyperthyroidism in cats. The most commonly used drug in a transdermal patch in the cat is fentanyl. A compounded medicine that is regularly seen by the ncc team is a product called transdermal methimazole for cats. Clinical efficacy and safety of transdermal methimazole in the. It is either given by mouth or applied topically to the skin. Methimazole lowers the amount of thyroid hormone made by the thyroid gland.
Trouble regulating hyperthyroid cat with methimazole. Methimazole is used to treat hyperthyroidism overactive thyroid. Methimazole treats the disease by reducing the amount of thyroid hormone produced. Methimazole is used to treat overactive thyroid hyperthyroidism. Medication does not cure hyperthyroidism, but it does keep it under control so that missy can lead a normal life. Methimazole is a prescription medication used by veterinarians to treat overactive hyper thyroid in cats. The pharmacokinetics of methimazole, either applied in the form of a 5 % topical formulation to facial skin or taken orally in the form of a 5 mg tablet by 6 volunteers, were determined. Cat does not seem to be getting better, does this dosage sound right. In contrast, a pharmacodynamic study of transdermal methimazole gel showed a positive response to therapy, including normalization of serum t4 in hyperthyroid cats. Compounding pharmacies can make a flavored oral liquid form or transdermal topical gel, which may be easier to give. Existing patches are limited in size to about 50 cm2 square, and the stratum corneum limits transdermal delivery to about 1 mg per cm2.
With just two steps, a nomess applicator, and no tiny markings to read, you can rest assured that patients will receive the prescribed amount of medication while reducing exposure to the pet owner. Methimazole twistadose transdermal gel wedgewood pharmacy. If you find that the transdermal gel eventually doesnt do the trick, and you. Applying transdermal methimazole is as easy as gently massaging inside the tip of her ear. Pdf safety of topical methimazole for the treatment of. Methimazole may also be used for purposes not listed in this medication guide. If youre tired of wrestling with tabby to get her to take her thyroid.
Amitriptylinemethimazole twistadose transdermal gel. It also is used before thyroid surgery or radioactive iodine treatment. The starting dose of 10 mg once daily for transdermal methimazole and 5 mg twice daily for oral carbimazole was chosen for this study based on published studies. It is available as a transdermal gel or as an oral tablet. It is used by vets to treat feline hyperthyroidism which occurs. Thirteen cats, newly diagnosed with hyperthyroidism, were treated with a transdermal formulation of methimazole at a dose of 5 mg 0. International journal of pharmaceutical compounding, vol. Transdermal methimazole for felines pharmacy solutions. Common side effects include vomiting, anorexia, and tiredness, but more. The medication used in the transdermal gel is the same as the tablets manufactured commercially but the difference is the delivery of the medication. Among the new drug delivery systems is the use of transdermal applications. The topical application of transdermal methimazole is an ideal route of administration for cat owners. I was diagnosed with graves disease nearly one year ago.
Your doctor may start you at a dose ranging from 5 mg to 20 mg every 8 hours. What is the dosage of the transdermal methimazole given to. Hyperthyroidism medication for cats methimazole veterinary. If you have a hard time getting your patients to take their medications in the dosage forms youve prescribed, try one of wedgewood pharmacys unique dosage forms that may help increase compliance.
Published data indicate that transdermal methimazole is not as rapidly acting or as effective as oral dosing, but it can be effective to reduce t 4 concentrations in many cats. A methimazole gel is also available as a transdermal preparation 50 mg ml, summit pharmaceuticals. I have continually reduced my methimazole every two months. Methimazole is not fda approved for use in veterinary medicine.
235 363 593 686 78 317 1232 530 1538 1151 563 167 1354 391 664 97 460 922 530 814 752 1004 243 627 51 1377 941 930 1424 490 958 966 1336 527 746 391